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Jul
3
Sandeep Singh Dhillon
Supply Chain Manager – Novartis
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Job Description

Job ID 214902BR
Position Title : Supply Chain Manager
Division Novartis Technical Operations
Business Unit NTO SUPPLY CHAIN
Country : Malaysia
Work Location : Petaling Jaya
Company/Legal Entity : NOV MALAYSIA
Functional Area : Technical Operations
Job Type : Full Time
Employment Type : Regular

•Responsible for implementation of global SCM processes and initiatives
•Facilitation and implementation of local S&OP process and forecasting with the Sales & marketing team
•Responsible for proper Net Requirement Planning and Order Management
•Review/evaluate demand data of active assortment items coming from the business units/product management vs. rules and assumptions
•Provide demand data to global demand and supply planning
•Planning and managing physical levels of stockholding.
•Controlling movement of each individual item closely to meet unexpected short term variations and deviations
•Up-to-date and accurate submission of demand files to SCM.
•SKUs reductions & pruning program
•Demand planning & tracking analysis on stock forecast requirement and accurate data and ensure timely submission
•Timely transmission of monthly sales & inventory reporting
•Establish & integrate local processes in alignment to GISC processes.
•Fine-tune and enhance if necessary the control parameters within the inventory system and all decision-related processes in the total logistic operation.
•Identifying areas of best cost trade-off for all inter-related activities within both our distributors’ networks which will optimize the efficiency of the total distribution process.
•Maintaining high level of inventory record accuracy
•Ensure all relevant data and documentation for both sales & inventory transactions are up-to-date and in-line for a smooth, accurate and fast month end closing
•Build and maintain supplier relationships to secure continuity of supply and support business goals
•Participate as part of a cross-divisional team to identify reliable, cost-effective, good quality suppliers for both new and existing products
•Product Lifecycle Management Launches: support new launches and make sure that all milestones are met.

Minimum requirements

•University degree in supply chain management, business administration or Commercial degree.
•Fluent in English
•3-5 years experience in supply chain management, and works independently
•Ability to lead and drive initiatives and projects with minimum supervision
•Excellent organizational, planning skills, and effectiveness in a complex environment, as well as ability to communicate throughout different cultures, functions and hierarchies.
•Good understanding of the (generic) pharmaceutical industry is preferred (awareness of regulatory procedures, Quality assurance, and patent issues)
•Sound knowledge of ERP

Apply here at 

https://sjobs.brassring.com/tgwebhost/jobdetails.aspx?jobid=2488035&jobreqlang=140&jobsiteid=5260&jobsiteinfo=2488035_5260&gqid=0&partnerid=13617&siteid=5268&type=mail

Aug
5
Sandeep Singh Dhillon
What you need to know about immediate, delayed and extended-release medications – MIMS Malaysia
Formulation Discussion, Pharma Notables
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Recognising correct drug formulation is an important aspect of medical treatment. There are distinct pharmacokinetic differences between oral formulations such as immediate-release, extended-release and delayed-release although the drug composition and strength are identical. Unfortunately, these distinctions may not be apparent to many doctors or pharmacists, and the specific terms may be incorrectly used interchangeably. In addition, new formulations of the same pharmaceutical ingredients frequently enter the market, thus creating more confusion.

Henceforth, it is pivotal for both doctors and pharmacists to understand the fundamental differences between various formulation types to ensure optimum treatment. For pharmacists, failure to recognize and dispense the correct formulation may constitute negligence which can directly cause harm to patients.
Immediate-release formulation

The most commonly seen formulation in Malaysia is the immediate-release medication. These standard drug products are designed to release the active pharmaceutical compound immediately after the outer shell of tablets/capsule dissolves. There is no deliberate attempt to modify the release profile. For highly soluble drugs, this may result in rapid absorption and fast systemic entry into the body, i.e. a prompt increase in blood concentration of that particular drug. The accompanying clinical effect will be seen as soon as the plasma concentration reaches the therapeutic level (1).

There are exceptions to the above-mentioned observation. Some medicines are formulated as pro-drugs, which mean the pharmaceutical compound itself does not have therapeutic effects until it undergoes hepatic metabolism and transformed into the active compound. In this case, the pharmacodynamic effect may not be apparent until there is enough conversion of the pro-drugs into their active form. Alternatively, many drugs which are poorly soluble (i.e. lipophilic) may not be rapidly absorbed, thus delaying its clinical effect (1).
Modified-release formulation

On the other hand, modified-release formulations are specially designed to alter the drug release profile, thereby favourably affecting the absorption time and subsequent pharmacodynamic effects. The term “modified release” is rather all-encompassing, including many different types of formulations currently available in the market such as extended-release and delayed-release formulation.
Extended-release formulation

Extended-release formulation allows at least twofold reduction in dosage frequency as compared to the immediate-release ones, as described in Applied Biopharmaceutics & Pharmacokinetics (1). Several technologies have been successfully employed to control drug release profiles, such as microencapsulation and diffusion systems.
Know the differences

When compared to delayed-release dosage forms, there are many similarities amidst some distinct differences. A delayed-release product is a formulation that only releases the medication until the tablet has passed through the stomach, as explained by Fava and Holquist (2).

To illustrate the differences between extended- and delayed-release, one can refer to the case of Depakote (divalproex sodium) formulations. Depakote received attention from the medical community, especially the US FDA when the agency received a couple of medication errors pertaining to a mix-up of extended- and delayed-release formulation. Depatoke is indicated for the treatment of manic episode in patients with bipolar disorder whom lithium is contraindicated or not tolerated (3).

Existing pharmacokinetic data indicated that there were significant differences between the plasma concentration profile for both dosage forms. The bioavailability of extended-release Depakote was 10% less than an equivalent dose of delayed-release formulation (2).

It is vital for pharmacists to be aware of such differences for many other drugs. These different dosage forms commonly appear to be comparable to each other in terms of visual similarities and sound-alike names. Vigilance is a valuable trait when prescribing or dispensing such medications. MIMS

Reference:
1. Shargel L, Wu-Pong S, Yu A. Chapter 17. Modified-Release Drug Products. Applied Biopharmaceutics & Pharmacokinetics. 6th Editio. New York: McGraw-Hill Medical; 2012.
2. Fava W, Holquist C. FDA safety page: Delayed-release vs. extended-release Rxs [Internet]. Drug Topics – Voice of the pharmacist. 2007 [cited 2016 Jul 20]. Available from: http://drugtopics.modernmedicine.com/drug-topics/news/clinical/pharmacy/fda-safety-page-delayed-release-vs-extended-release-rxs?page=full
3. Sanofi. Depakote 250mg Tablets [Internet]. eMedicine Compendium. 2009 [cited 2016 Jul 20]. Available from: https://www.medicines.org.uk/emc/medicine/25929

Jul
8
sandeepsd
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Required! – Quality Manager: Pharmaceuticals Orlando, FL
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31
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Practical Stability Study Application to Pharmaceuticals (5 – 7 October 2015)
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28
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Formulation Discussion
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21
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ICH Guidelines Q1A – Q1F Stability
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