Pharma Job! Bioinformatics Sr. Manage...
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Pharma Job! Bioinformatics Sr. Manager/Associate Director Seattle Genetics, Inc.
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Bothell, WA

Posted Date:


Position Type:

Full time

Job Code:


Required Education:


Areas of Expertise Desired:


Job Description

Primary Role
Lead and collaborate with cross-functional colleagues on devising and executing bioinformatics strategies across all therapeutic areas at Seattle Genetics; these strategies aim to understand disease pathogenesis and progression, drug mechanism of action, and factors impacting response to therapies.  Lead the establishment of cross-functional state-of-the-art bioinformatics tools and processes, mentor other bioinformatics scientists, and provide hands-on analyses.

Key Responsibilities
•   Lead or guide cross-functional teams that develop and implement bioinformatics analysis strategies for drug development programs, to:
o   Integrate multi-modal multi-analyte clinical (and preclinical, where appropriate) biomarker data from internal studies and the literature to understand disease pathogenesis & progression, drug mechanism-of-action, and response (safety, efficacy, and pharmacodynamic) to therapies
o   generate testable hypotheses, design experiments, and incorporate appropriate biomarker/pharmacodynamic assessments in study protocols
o   assess patient stratification (prognostic & diagnostic markers), drug positioning and predictive modeling using state-of-the-art bioinformatics tools and techniques
•   Communicate analyses results and interpretation to cross-functional matrix teams of biomarker leads, clinicians, biostatisticians, research scientists, and clinical pharmacologists
•   Collaborate with Biometrics, Information Technologies, Biomarkers/Diagnostics, Clinical Pharmacology, and other functions to establish and strengthen Bioinformatics infrastructure/systems
•   Lead resource planning, budgeting, and hiring in Bioinformatics, mentor junior bioinformatics scientists; select, hire and monitor qualified and cost-effective contractors, consultants, and/or CROs
•   Participate in the establishment of policies, standards, and guidance for the operation of the Bioinformatics group


Desired Skills and Experience
–   Ph.D. in Bioinformatics, Computational Biology, Biostatistics/Statistics or related field with at least 7 years relevant experience in biotech, pharma or academia; management experience highly preferred
–   Drug development experience in oncology and inflammation and strong understanding of disease biology in these therapeutic areas
–   Working experience in the biotech/pharma industry, preferably in clinical research
–   Strong background in Omic (RNA, proteomic, epigenetic) data analysis and biological interpretation; proficiency with biostatistics and data mining methodologies in conducting supervised and unsupervised analysis of Omic data
–   Proficiency using R /SAS and Bioconductor packages, commercial bioinformatics tools (ArrayStudio, Partek), data visualization tools (Spotfire, Cytoscape), molecular pathway analysis tools (Metacore, IPA), related languages (Java, C#, XML, Perl, C, C++, SQL) and commercial and publicly available biological databases (ArrayExpress/GEO, Oncomine, TCGA, 1000 Genomes etc.)
–   Proficiency with integration of multi-modal multi-analyte biomarker data with clinical data and knowledge management platforms.
–   Proficiency with modeling and simulation of disease pathogenesis and drug mechanism of action
–   Familiarity with regulatory submissions, including NDA/BLA or PMA, in a relevant therapeutic area; understanding of ICH guidelines and regulatory requirements
–   Ability to communicate effectively with clinicians, research & biomarker scientists, clinical pharmacologists, biostatisticians and computational scientists
–   Ability to explain bioinformatics technical issues to technical and non-technical staff

Seattle Genetics is an equal opportunity employer.  All qualified applications will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status, or disability status.

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