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Aug
10
Sandeep Singh Dhillon
Senior Scientist, Organic Synthesis – Pacific Biosciences (Glassdoor US)
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Senior Scientist, Organic Synthesis

Location: Menlo Park, CA

Pacific Biosciences is looking for a Scientist/Senior Scientist, Organic Synthesis to manufacture our fluorescent compounds. In this position the person will work on process optimization, scale-up and manufacturing of the targeted compounds. The candidate will need to be capable of performing activities required while developing and optimizing the synthesis and purification processes associated with our dye labeled compounds for yield, performance and quality. This position requires in-depth relevant experience in organic synthesis with the capability to support and maintain robust, reliable and accurate processes in manufacturing.

This person will interface with a broad range of functional groups, and needs to have good communication skills. As a developer, this person will be responsible for correlation of processes and physical specifications to system performance metrics.

Responsibilities:
  • Route selection for the most efficient way to synthesize the required compounds.
  • Extensive lab work designing and executing experiments, and analyzing resultant data.
  • Process optimization and scale-up.
  • Establishing the right set of the documentation, related to products production.
  • Collecting and analyzing the analytical data.
Position Requirements:
  • Ph.D. in Organic Chemistry with 3+ years of relevant experience in Pharmaceutical industry.
  • Extensive experience in organic synthesis, process optimization and scale-up.
  • Experience in fluorescent dyes and nucleotide synthesis is highly desirable.
  • Strong knowledge in purification methods and analytical techniques.
  • Knowledge and work experience in GMP environment is a plus.
  • Strong communication skills, team work and initiative.
  • Appreciation of process quality and specifications as a requirement for manufacturing.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
Aug
10
Sandeep Singh Dhillon
Scientist, Small Molecule Pharmaceutics, Genentech Research – San Francisco (Glassdoor US)
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Job Description

Scientist, Small Molecule Pharmaceutics, Genentech Research
South San Francisco, California
United States

Job ID: 00453071

The Position

We are seeking a Scientist to support drug discovery in the Department of Small Molecule Pharmaceutics at Genentech. The primary responsibilities for this role extend from formulation and pharmaceutics support from early stage research to late stage research, IND-enabling safety studies, and informing development strategy for clinical formulation. This person will primarily be responsible for pharmaceutical profiling and drug delivery approaches during preclinical assessment of novel small molecule therapeutics for unmet medical needs.

The successful candidate is expected to:
Drive scientific and technical innovation collaboratively with other members of Discovery teams and within Small Molecule Pharmaceutical Sciences.
Focus on selection, profiling and advancing small molecule clinical candidates in a scientifically rigorous, phase-appropriate manner
Develop and execute pre-formulation and preclinical formulation strategies based on strong scientific rationale and pharmaceutical/biopharmaceutical properties of molecules for one or more projects
Based on preclinical knowledge, identify potential risks during clinical formulation development.
Leverage preclinical knowledge, participate in key decisions such as physical form selection and clinical formulation design
Have a proven track record of publication in high quality scientific journals
Participate and thrive in an interactive, collaborative, team-oriented culture, interfacing with discovery and early development functions
Who You Are

A Ph.D. in Pharmaceutical Sciences, Chemistry, Chemical Engineering or related fields with 3-8 years’ experience in the pharmaceutical industry. Knowledge and expertise in the interplay between molecular physicochemical properties, absorption processes, and pharmacokinetic/pharmacodynamic (PK/PD) relationships with formulation modality is required. Experience in working within the drug discovery space is highly desired. Additionally, experience in alternative therapeutic modalities (such as peptides, etc.) and drug delivery technologies (such as inhalation, ocular, topical, etc.) is highly valued.

The successful candidate must have excellent communication skills, interpersonal skills,
and problem-solving skills, as well as demonstrate the ability to plan, design, implement and analyze laboratory experiments to advance projects and guide formulation selection and development.

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

Apply at https://www.gene.com/careers/detail/00453071/Scientist-Small-Molecule-Pharmaceutics-Genentech-Research?src=SNS-15161

Jul
28
Sandeep Singh Dhillon
Validation Engineer – BioPharm at Mangan Inc Cambridge, MA 02238 – Monster.com
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Company Description
Mangan Biopharm is a subsidiary division of Mangan Inc. and is a full service Engineering and Life Science Quality and Compliance Company. Mangan has over 25 years of experience in Engineering, Procurement and Construction with 15+ years of experience in Lifesciences Engineering and Compliance Consulting. We are customer-centric and fully committed to our clients needs and as a result, most of our business is repeat business.

Job Description

Position Summary:

The Validation Engineer is responsible for execution of validation projects for equipment, facilities, and utilities in a pharmaceutical manufacturing, packaging, or support environment. The candidate must be able to work independently, but be able to coordinate execution efforts with operations, manufacturing, facilities, laboratories, development, materials management and quality assurance personnel. This role will play an integral part in overall project success.

Duties:

Validation Engineer I ( 2 – 5 years of Experience/Salary range $60 to $80k)

 Reviews validation packets for completeness and accuracy, sound rationale, compliance with validation policies and procedures, and accurate data analysis. Compares results against acceptance criteria and bring exceptions and deviations to management’s attention

 Maintains appropriate validation documentation and files in accordance with regulatory requirements and internal procedures

 Effectively apply validation methodology and standards

 Support, investigate and troubleshoot problems and determine solutions

 Provide technical assistance during investigations of process /equipment / cleaning / validation issues. Generate and resolve validation deviations / protocol discrepancies

Validation Engineer II ( 5 – 9 years of Experience/Salary range $80 to $100k)

 Analyze validation data, prepare summary reports and provide recommendations for improvement in manufacturing process and equipment

 Develop training packages, JSAs and writing Best Known Methods (BKM) for Validation

 Serve as a dependable liaison between validation and manufacturing

 Identify, respond to and monitor potential project risks and determine possible contingency plans for risk mitigation

 Reviews technical and quality system documents such as SOPs, Change Control and Deviation Reports, Batch Production Records, Technical Manuals, P&IDs, construction, as-built, flow diagrams as they relate to validation principles and regulatory compliance issues

Qualifications:

 Bachelor’s degree in engineering, science or related field

 Excellent organization and time management skills

 Good understanding of cGMP validation requirements / guidelines and current industry practices

 Results-oriented, able to make decisions, and able to prioritize validation project and client needs

 Strong teamwork and collaboration

 Must have excellent interpersonal, technical writing and communication skills

 Proficient in use of MS Office software suite

 Ability to work occasional off shift and/or weekends to accommodate schedules and/or project timelines

Apply at http://job-openings.monster.com/Validation-Engineer-BioPharm-Cambridge-MA-US-Mangan-Inc/11/186239493?JDNJobDocument.JobID=132549024&AdID=28361036&ImpressionGuid=fdaae5cd-6b40-2429-c1c6-3566f228ad51&AffiliateGuid=63315516-d696-4397-af9e-806bf6170167&CampaignID=240301&Premium=0&RendererID=2146&code=-1&unit=-1&stracking=&WT.mc_n=JDN000003

Jul
28
Sandeep Singh Dhillon
Pharmaceutical Formulation Development Advisor at UPM Pharmaceuticals
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About the Job

Pharmaceutical Formulation Development Advisor

UPM Pharmaceuticals, Inc., (upm-inc.com) a rapidly growing contract drug development and manufacturing company for the pharmaceutical industry, located in Bristol, Tennessee, is seeking two senior advisors/guides for pharmaceutical formulation development.

Essential Duties and Responsibilities: This role requires experienced formulation and process development scientists with project leadership experience in development of pharmaceutical solid oral dosage form products and manufacturing processes. Will provide science & technology guidance in support of client projects in various product development and manufacturing activities within time and budget constraints. Guidance will be provided to all levels within R&D, Manufacturing, Business Development, Quality, and Executive Management. Major activities include: contract proposal review; business development support; technical guidance for project leaders and participation in design of formulations and manufacturing processes; evaluation & implementation of new technology & equipment; attend team meetings; review documents; answer technical questions and participate in discussions; presence on mfg floor or lab during critical operations; write technical reports; advise on procedural, document, and batch record questions; advise registration and validation activities; and many other lesser activities.

Qualifications:

Pharmaceutical formulation development experience is required. Preference for CDMO (contract development and manufacturing operation) experience with solid oral dosage forms and a PhD, but not required.

Academic study of industrial & physical pharmacy, pharmaceutical chemistry, chemical engineering, chemistry, or biochemistry; skill in the science & art of pharmaceutical product development; experience & knowledge of pre-formulation, formulation development, clinical manufacturing, analytical testing, quality control & assurance, cGMP, & GLP; knowledge of programs like Outlook, Word, Excel, Access, TrackWise, and Documentum; knowledge of contract development, concept product development, clinical phase 1, 2, and 3, bio batch, registration, and validation; experienced with IND/NDA/ANDA, QBD, CPP, DOE, and RLD activities; detail oriented, a self-starter, excellent organization & communication skills; ability to handle multiple tasks involving various departments in a fast-paced environment; effective interpersonal skills; ability to read, analyze, interpret, & write scientific documents/reports; the will & ability to achieve success.

Apply at

http://job-openings.monster.com/Pharmaceutical-Formulation-Development-Advisor-Bristol-TN-US-UPM-Pharmaceuticals/11/185132690

Jul
19
Sandeep Singh Dhillon
Compliance Engineer – Pharmaceutical Manufacturing (United Kingdom)
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Job Description
Compliance Engineer – Pharmaceutical Manufacturing Do you want to work for a company manufacturing the next generation of pharmaceutical products? Do you have a strong background in engineering? Have you got a good knowledge of CMMS systems and reliability centred maintenance? If so, I am looking to speak to you!

The company are developing a strong engineering team to add to their existing engineers as the manufacturing site grows and continues to develop new products for manufacture.

THE SALARY/RATE/PACKAGE/BENEFITS

Compliance Engineer – Pharmaceutical Manufacturing

  • £35k – £40k – DOE
  • Start ASAP
  • Pension, Healthcare and life assurance

THE CANDIDATE

Compliance Engineer – Pharmaceutical Manufacturing

You will be a qualified engineer with experience working in pharmaceutical or other FDA / MHRA regulated industries.

  • A good knowledge of maintenance including RCM will be essential for this position
  • Experience dealing with compliance issues and resolving problems whilst implementing robust systems to avoid any reoccurring problems
  • A good understanding of pharmaceutical documentation and best practice

THE ROLE

Compliance Engineer – Pharmaceutical Manufacturing

This is a position for an engineer who is looking to take responsibility for developing the CMMS system and becoming the system owner. As such you will have an engineering background coupled with knowledge of pharmaceutical manufacturing (GMP, FDA regulations)

After the development of the CMMS system you will work closely in all areas of engineering overseeing compliance issues and providing solutions to the problems encountered ensuring compliance remains at the forefront of everyone’s mind in order to meet the stringent MHRA, FDA and GMP standards.

This is a really interesting company to join at a key time in the development of their engineering function, as such opportunities to progress and develop will become available as the site grows.

If you want to find out more about the position, please call directly or apply below.

REFERRAL INFORMATION

Please submit your CV via email to apply in the first instance. We offer referral fees to those recommending unique applicants we go on to place. Do you know anyone suitable?

Location: Kent, Maidstone, Sittingbourne, Rochester

Jul
19
Sandeep Singh Dhillon
Pharmaceutical Scientists – Amoria Bond – Bury St Edmunds, England
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Scientist – South East EnglandAmoria Bond are working with an south east-based organisation who require support to capitalise on the potential to establish a prominent position in the pharma market.

The successful Scientist will offer support and expertise in synthetic chemistry, whilst working within a dynamic team including API functions and when required, communicating technical material both internally and externally.

We ideally require degree and masters degree holders, an appreciation of multiple analytical techniques, as well as experience within API environments.

Amoria Bond operates as an employment agency and employment business. No terminology in this advert is intended to discriminate on the grounds of age, and we confirm that we are happy to accept applications from persons of any age for this role.

Company Info
Website : www.amoriabond.com/en
Headquarters : Manchester, England
Size : 51 to 200 employees
Founded : 2006
Type Company – Private
Industry : Business Service
Revenue : $25 to $50 million (USD) per year
Competitors :  Unknown
One of the fastest growing recruitment companies, we have offices currently in Manchester, Amsterdam, Cologne and Singapore. Part of our mission is to be the best company in which the best recruiters can practice the recruitment profession and we are dedicated to hiring motivated individuals who have the potential and desire to be the the best they can be. To support this we provide an ongoing training and development program, which is consistently voted as the best in the industry.
Mission: “To be the best company in which the best recruiters can practice the recruitment profession. Giving unrivaled progression, training, development and support to enable us to give the highest quality global service to our clients and candidates through an ethical and professional approach.”

Jul
12
Sandeep Singh Dhillon
Senior Scientist – Pharmaceutical, Technical Transfer
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Astrix Technology Group

About the Job

Senior Scientist

Location: Wilmington, DE

CRITICAL CRITERIA
Must have Pharma background and oral solid dose experience
Experience with transferring product manufacturing internationally
Proficient with pulling and analyzing data

Description
The Senior Scientist role is responsible for aiding in the supply of strategic drug product technical expertise and support to a portfolio of established products
The products are manufactured either internally at a company manufacturing site or externally at a contractor
The technical expertise and support is used in problem solving as well as in continuous improvement activities
This a great opportunity to learn about the company’s exciting and diverse established product portfolio and to gain experience working in a Global function and with external suppliers

Responsibilities
Support License to Operate activities
Provide technical expertise and problem-solving support to the manufacturing sites
Provide technical expertise and support in creating regulatory documentation and responses to regulatory questions in a way that ensures maximum flexibility for Operations
Support manufacturing and supply chain changes
Perform technical risk assessments for proposed changes, e.g. to excipients, packaging/device components, manufacturing processes and/or analytical testing methods
Propose experimental work to support changes
Review generated data and make recommendations on whether to proceed with changes or not
Maintain product knowledge
Write reports and memos to record technical investigations or recommendations, ensuring data integrity
Contribute to and/or coordinate Quality Risk Assessments and Technical Opportunity and Risk Assessments (TORAs) as required
Produce and maintain information in the Product Knowledge Management tool
Coordinate, lead or support product improvement initiatives
As required, ensure delivery of product and process improvements that will deliver business benefits
Develop or support the manufacturing sites in developing business cases
Co-ordinate appropriate support teams if required
Maintain communication to product stakeholders
Work with Product Champions to receive work requests, perform priority assessments and agree level of effort on each activity
Establish networks between sites who manufacture the same or similar products to ensure effective collaboration
Effectively communicate product performance and product issues to the manufacturing sites
Build technical understanding and capability
Train manufacturing sites in, e.g. pharmaceutical technologies, formulation and packaging design, manufacturing and testing control strategies and analytical techniques as appropriate

Minimum Requirements
BS degree in a relevant discipline, e.g. analytical chemistry, chemical engineering or pharmaceutics
Preferred: Master’s Degree or PhD in a relevant discipline, e.g. analytical chemistry, chemical engineering or pharmaceutics
Experience of pharmaceutical manufacturing/QC testing and/or research and development
Knowledge of the overall drug development and commercialization process from development, launch and through life cycle management
Experience working in one of the following disciplines: Analytical Science, Chemical Science, Formulation Science, Physical Science, Pharmaceutical Manufacturing and Supply Chain Management
Knowledge of international GMP and SHE requirements and their applicability to pharmaceutical manufacturing, research, and development
Knowledge of Quality Management Systems and their applicability to pharmaceutical manufacturing
Experience working in Global function and/or with external parties

Skills & Capabilities
Business awareness – knowledge of company; its policies, organization, and culture, established products and development pipeline
Strong ability to work both independently and collaboratively across boundaries- cross-functionally, cross-culturally
Strong conceptual and strategic thinking skills
Good flexibility and change enablement capabilities
Good business relationship management and influencing skills
Good project and portfolio management skills
Ability to cascade knowledge through training and education

For interested candidates, please apply at

http://job-openings.monster.com/Senior-Scientist-Pharmaceutical-Technical-Transfer-Wilmington-DE-US-Astrix-Technology-Group/11/186100861?MESCOID=1900254001001&jobPosition=7

Jul
3
Sandeep Singh Dhillon
Supply Chain Manager – Novartis
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Job Description

Job ID 214902BR
Position Title : Supply Chain Manager
Division Novartis Technical Operations
Business Unit NTO SUPPLY CHAIN
Country : Malaysia
Work Location : Petaling Jaya
Company/Legal Entity : NOV MALAYSIA
Functional Area : Technical Operations
Job Type : Full Time
Employment Type : Regular

•Responsible for implementation of global SCM processes and initiatives
•Facilitation and implementation of local S&OP process and forecasting with the Sales & marketing team
•Responsible for proper Net Requirement Planning and Order Management
•Review/evaluate demand data of active assortment items coming from the business units/product management vs. rules and assumptions
•Provide demand data to global demand and supply planning
•Planning and managing physical levels of stockholding.
•Controlling movement of each individual item closely to meet unexpected short term variations and deviations
•Up-to-date and accurate submission of demand files to SCM.
•SKUs reductions & pruning program
•Demand planning & tracking analysis on stock forecast requirement and accurate data and ensure timely submission
•Timely transmission of monthly sales & inventory reporting
•Establish & integrate local processes in alignment to GISC processes.
•Fine-tune and enhance if necessary the control parameters within the inventory system and all decision-related processes in the total logistic operation.
•Identifying areas of best cost trade-off for all inter-related activities within both our distributors’ networks which will optimize the efficiency of the total distribution process.
•Maintaining high level of inventory record accuracy
•Ensure all relevant data and documentation for both sales & inventory transactions are up-to-date and in-line for a smooth, accurate and fast month end closing
•Build and maintain supplier relationships to secure continuity of supply and support business goals
•Participate as part of a cross-divisional team to identify reliable, cost-effective, good quality suppliers for both new and existing products
•Product Lifecycle Management Launches: support new launches and make sure that all milestones are met.

Minimum requirements

•University degree in supply chain management, business administration or Commercial degree.
•Fluent in English
•3-5 years experience in supply chain management, and works independently
•Ability to lead and drive initiatives and projects with minimum supervision
•Excellent organizational, planning skills, and effectiveness in a complex environment, as well as ability to communicate throughout different cultures, functions and hierarchies.
•Good understanding of the (generic) pharmaceutical industry is preferred (awareness of regulatory procedures, Quality assurance, and patent issues)
•Sound knowledge of ERP

Apply here at 

https://sjobs.brassring.com/tgwebhost/jobdetails.aspx?jobid=2488035&jobreqlang=140&jobsiteid=5260&jobsiteinfo=2488035_5260&gqid=0&partnerid=13617&siteid=5268&type=mail

Jun
30
Sandeep Singh Dhillon
Commissioning/Validation Engineer (cGMP – Pharmaceutical) at DPS Engineering Lexington, MA (Monster.com)
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About the Job

Validation Engineer (cGMP – Pharmaceutical) JD817697

Boston, MA area

Summary:

DPS Engineering is looking for multiple CQV resources to support major projects for various pharmaceutical clients in the Boston, MA and Southern NH areas. This individual will write and execute validation protocols for new and existing, facility utilities, and process equipment.

Responsibilities:

Write and execute validation protocols for new and existing equipment, facility utilities, and manufacturing processes.
Start-up C&Q experience of process and utility systems.
Be able to work as part of a large project team and be a system owner for a system.
Role will involve authoring and executing CQV documentation for a defined system against project schedule and timelines.
Deviation/Nonconformance write up and close out resolution.
Provide direction, input, review and approval of engineering studies, FAT, IQ, OQ, and PQ validation protocols and reports for facilities, equipment, systems and utilities to ensure thoroughness, accuracy and compliance with company policies.
Provide technical troubleshooting and creative solutions to manufacturing process challenges.

Qualifications:

Bachelor’s degree (preferably in an engineering discipline).
Relevant engineering, scientific or related discipline.
5+ years professional experience in a biologics/pharmaceutical.
Experience developing and executing process, equipment, and cleaning validation protocols.
Knowledge of cGMP practices and standards.
Excellent written and verbal communication and interpersonal skills; prefer an individual with a positive, results oriented, team mindset and capable of changing direction and focus as priorities shift.

Apply at http://job-openings.monster.com/Commissioning-Validation-Engineer-cGMP-Pharmaceutical-Lexington-MA-US-DPS-Engineering/11/185029109?MESCOID=1700192001001&jobPosition=8

Jun
30
Sandeep Singh Dhillon
Vacancy – Pharmaceutical Formulation Development Advisor at UPM Pharmaceuticals – Monster.com
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About the Job

Pharmaceutical Formulation Development Advisor

Bristol, TN 37620

UPM Pharmaceuticals, Inc., (upm-inc.com) a rapidly growing contract drug development and manufacturing company for the pharmaceutical industry, located in Bristol, Tennessee, is seeking two senior advisors/guides for pharmaceutical formulation development.

Essential Duties and Responsibilities: This role requires experienced formulation and process development scientists with project leadership experience in development of pharmaceutical solid oral dosage form products and manufacturing processes. Will provide science & technology guidance in support of client projects in various product development and manufacturing activities within time and budget constraints. Guidance will be provided to all levels within R&D, Manufacturing, Business Development, Quality, and Executive Management. Major activities include: contract proposal review; business development support; technical guidance for project leaders and participation in design of formulations and manufacturing processes; evaluation & implementation of new technology & equipment; attend team meetings; review documents; answer technical questions and participate in discussions; presence on mfg floor or lab during critical operations; write technical reports; advise on procedural, document, and batch record questions; advise registration and validation activities; and many other lesser activities.

Qualifications:

Pharmaceutical formulation development experience is required. Preference for CDMO (contract development and manufacturing operation) experience with solid oral dosage forms and a PhD, but not required.

Academic study of industrial & physical pharmacy, pharmaceutical chemistry, chemical engineering, chemistry, or biochemistry; skill in the science & art of pharmaceutical product development; experience & knowledge of pre-formulation, formulation development, clinical manufacturing, analytical testing, quality control & assurance, cGMP, & GLP; knowledge of programs like Outlook, Word, Excel, Access, TrackWise, and Documentum; knowledge of contract development, concept product development, clinical phase 1, 2, and 3, biobatch, registration, and validation; experienced with IND/NDA/ANDA, QBD, CPP, DOE, and RLD activities; detail oriented, a self-starter, excellent organization & communication skills; ability to handle multiple tasks involving various departments in a fast-paced environment; effective interpersonal skills; ability to read, analyze, interpret, & write scientific documents/reports; the will & ability to achieve success.

Apply at http://job-openings.monster.com/Pharmaceutical-Formulation-Development-Advisor-Bristol-TN-US-UPM-Pharmaceuticals/11/185132690?MESCOID=1900254001001&jobPosition=7